Vascular Medicine Conference-CVC 2026

Endothelial dysfunction refers to a state where the endothelium—the delicate inner lining of blood vessels—experiences impaired function and loses its regulatory abilities over vascular tone, blood flow, and coagulation. This condition is recognized as an early indicator of atherosclerosis and is closely linked to the onset of cardiovascular diseases, including hypertension, coronary artery disease, and stroke. Factors commonly associated with endothelial dysfunction include elevated blood pressure, hypercholesterolemia, diabetes mellitus, tobacco use, obesity, and chronic systemic inflammation.

Clinically, endothelial dysfunction may remain asymptomatic in its early stages, yet it significantly increases the risk of serious vascular events over time. Management strategies primarily target the modification of underlying risk factors and the restoration of normal endothelial activity. Key interventions encompass regular physical activity, adherence to a nutrient-rich diet high in antioxidants, cessation of smoking, and effective weight management. Pharmacological therapy—such as antihypertensive, lipid-lowering, and antidiabetic agents—may also be necessary to optimize cardiovascular risk profiles. Early diagnosis and comprehensive management are crucial for improving endothelial health, mitigating the progression of atherosclerotic disease, and reducing the likelihood of adverse cardiovascular outcomes.